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Contribution of human cytochrome P-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine
1. The aim of the present study was to identify human cytochrome P-450 isoforms (CYPs) involved in 5-sulphoxidation and N-demethylation of the simplest phenothiazine neuroleptic promazine in human liver. 2. The experiments were performed in the following in vitro models: (A) a study of promazine met...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573803/ https://ncbi.nlm.nih.gov/pubmed/12721102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705195 |
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