Crotonylation at Serine 46 Impairs p53 Activity

Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty acid modification of p53 in human cells. Crotonic acid (CA) treatment induce...

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Foilsithe in:Biochem Biophys Res Commun
Main Authors: Liao, Peng, Bhattarai, Nimisha, Cao, Bo, Zhou, Xiang, Jung, Ji Hoon, Damera, Krishna, Fuselier, Taylor T, Thareja, Suresh, Wimley, William C, Wang, Binghe, Zeng, Shelya X, Lu, Hua
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703795/
https://ncbi.nlm.nih.gov/pubmed/32035620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.01.152
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