Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

TP53 missense mutations significantly influence the development and progression of various human cancers via their gain of new functions (GOF) through different mechanisms. Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocel...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Liao, Peng, Zeng, Shelya X, Zhou, Xiang, Chen, Tianjian, Zhou, Fen, Cao, Bo, Jung, Ji Hoon, Sal, Giannino Del, Luo, Shiwen, Lu, Hua
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204219/
https://ncbi.nlm.nih.gov/pubmed/29225033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.11.006
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