Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provides a landing pad for the peptidyl prolyl-isomerase Pin1, which in...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: D'Artista, Luana, Bisso, Andrea, Piontini, Andrea, Doni, Mirko, Verrecchia, Alessandro, Kress, Theresia R., Morelli, Marco J., Del Sal, Giannino, Amati, Bruno, Campaner, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008323/
https://ncbi.nlm.nih.gov/pubmed/26943576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7846
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