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Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells
p53-R249S (p53-RS) is frequently detected in human hepatocellular carcinoma (HCC) that is highly associated with hepatitis B infection and aflatoxin B1 exposure. Our previous study showed that CDK4/Cyclin D1 phosphorylates p53-RS at the cancer-derived Ser249 and promotes its interaction with c-Myc i...
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| 發表在: | Cancer Biol Ther |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7012101/ https://ncbi.nlm.nih.gov/pubmed/31747859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1685289 |
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