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Selectivity filter ion binding affinity determines inactivation in a potassium channel

Potassium channels can become nonconducting via inactivation at a gate inside the highly conserved selectivity filter (SF) region near the extracellular side of the membrane. In certain ligand-gated channels, such as BK channels and MthK, a Ca(2+)-activated K(+) channel from Methanobacterium thermoa...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Boiteux, Céline, Posson, David J., Allen, Toby W., Nimigean, Crina M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703589/
https://ncbi.nlm.nih.gov/pubmed/33154158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009624117
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