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Selectivity filter ion binding affinity determines inactivation in a potassium channel
Potassium channels can become nonconducting via inactivation at a gate inside the highly conserved selectivity filter (SF) region near the extracellular side of the membrane. In certain ligand-gated channels, such as BK channels and MthK, a Ca(2+)-activated K(+) channel from Methanobacterium thermoa...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7703589/ https://ncbi.nlm.nih.gov/pubmed/33154158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009624117 |
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