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Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition
LRH-1 is a nuclear receptor that regulates lipid metabolism and homeostasis, making it an attractive target for the treatment of diabetes and non-alcoholic fatty liver disease. Building on recent structural information about ligand binding from our labs, we have designed a series of new LRH-1 agonis...
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| 出版年: | Bioorg Med Chem Lett |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7701997/ https://ncbi.nlm.nih.gov/pubmed/32631515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127293 |
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