Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition

LRH-1 is a nuclear receptor that regulates lipid metabolism and homeostasis, making it an attractive target for the treatment of diabetes and non-alcoholic fatty liver disease. Building on recent structural information about ligand binding from our labs, we have designed a series of new LRH-1 agonis...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Cornelison, Jeffery L., Cato, Michael L., Johnson, Alyssa M., D’Agostino, Emma H., Melchers, Diana, Patel, Anamika B., Mays, Suzanne G., Houtman, René, Ortlund, Eric A., Jui, Nathan T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7701997/
https://ncbi.nlm.nih.gov/pubmed/32631515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127293
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