Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors

Twelve pyridazinones (T1–T12) containing the (2-fluorophenyl) piperazine moiety were designed, synthesized, and evaluated for monoamine oxidase (MAO) -A and -B inhibitory activities. T6 was found to be the most potent MAO-B inhibitor with an IC(50) value of 0.013 µM, followed by T3 (IC(50) = 0.039 µ...

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Veröffentlicht in:Molecules
Hauptverfasser: Çeçen, Muhammed, Oh, Jong Min, Özdemir, Zeynep, Büyüktuncel, Saliha Ebru, Uysal, Mehtap, Abdelgawad, Mohamed A., Musa, Arafa, Gambacorta, Nicola, Nicolotti, Orazio, Mathew, Bijo, Kim, Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7698448/
https://ncbi.nlm.nih.gov/pubmed/33212876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25225371
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