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Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies

Opioids are the drugs of choice in severe pain management. Unfortunately, their use involves serious, potentially lethal side effects. Therefore, efforts in opioid drug design turn toward safer and more effective mechanisms, including allosteric modulation. In this study, molecular dynamics simulati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Bartuzi, Damian, Kędzierska, Ewa, Kaczor, Agnieszka A., Schmidhammer, Helmut, Matosiuk, Dariusz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7697543/
https://ncbi.nlm.nih.gov/pubmed/33187107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228463
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