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Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies

Opioids are the drugs of choice in severe pain management. Unfortunately, their use involves serious, potentially lethal side effects. Therefore, efforts in opioid drug design turn toward safer and more effective mechanisms, including allosteric modulation. In this study, molecular dynamics simulati...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bartuzi, Damian, Kędzierska, Ewa, Kaczor, Agnieszka A., Schmidhammer, Helmut, Matosiuk, Dariusz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7697543/
https://ncbi.nlm.nih.gov/pubmed/33187107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228463
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