Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies

Opioids are the drugs of choice in severe pain management. Unfortunately, their use involves serious, potentially lethal side effects. Therefore, efforts in opioid drug design turn toward safer and more effective mechanisms, including allosteric modulation. In this study, molecular dynamics simulati...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Bartuzi, Damian, Kędzierska, Ewa, Kaczor, Agnieszka A., Schmidhammer, Helmut, Matosiuk, Dariusz
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7697543/
https://ncbi.nlm.nih.gov/pubmed/33187107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228463
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