Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate. Palmitate treatment increased saturated glycero...

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Publicado en:Mol Cell
Autores principales: Piccolis, Manuele, Bond, Laura M., Kampmann, Martin, Pulimeno, Pamela, Chitraju, Chandramojan, Jayson, Christina B.K., Vaites, Laura P., Boland, Sebastian, Lai, Zon Weng, Gabriel, Katlyn R., Elliott, Shane D., Paulo, Joao A., Harper, J. Wade, Weissman, Jonathan S., Walther, Tobias C., Farese, Robert V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696670/
https://ncbi.nlm.nih.gov/pubmed/30846318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.036
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