Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate. Palmitate treatment increased saturated glycero...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Piccolis, Manuele, Bond, Laura M., Kampmann, Martin, Pulimeno, Pamela, Chitraju, Chandramojan, Jayson, Christina B.K., Vaites, Laura P., Boland, Sebastian, Lai, Zon Weng, Gabriel, Katlyn R., Elliott, Shane D., Paulo, Joao A., Harper, J. Wade, Weissman, Jonathan S., Walther, Tobias C., Farese, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696670/
https://ncbi.nlm.nih.gov/pubmed/30846318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.01.036
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