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MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits
Gene editing nuclease represented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through either the error-prone non-homologous end joining or the homology directed repair pathways. To improve Cas9’s homology directed repair capacity, here we report the...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7695827/ https://ncbi.nlm.nih.gov/pubmed/33247137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19842-2 |
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