MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits

Gene editing nuclease represented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through either the error-prone non-homologous end joining or the homology directed repair pathways. To improve Cas9’s homology directed repair capacity, here we report the...

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Udgivet i:Nat Commun
Main Authors: Ma, Linyuan, Ruan, Jinxue, Song, Jun, Wen, Luan, Yang, Dongshan, Zhao, Jiangyang, Xia, Xiaofeng, Chen, Y. Eugene, Zhang, Jifeng, Xu, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695827/
https://ncbi.nlm.nih.gov/pubmed/33247137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19842-2
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