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Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting
Immunodeficient mice have been used predominantly in biomedical research. Realizing that large animal species may have an enhanced ability to predict clinical outcome relative to mice, we worked to develop immunodeficient rabbits by CRISPR/Cas9. We first demonstrated that multiplex embryo transfer e...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610260/ https://ncbi.nlm.nih.gov/pubmed/28939872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12201-0 |
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