Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

BACKGROUND: Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets. ATP directly activates the plasma membrane channel P...

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Bibliographic Details
Published in:	BMC Biol
Main Authors:	Wang, Wenbiao, Hu, Dingwen, Feng, Yuqian, Wu, Caifeng, Song, Yunting, Liu, Weiyong, Li, Aixin, Wang, Yingchong, Chen, Keli, Tian, Mingfu, Xiao, Feng, Zhang, Qi, Chen, Weijie, Pan, Pan, Wan, Pin, Liu, Yingle, Lan, Huiyao, Wu, Kailang, Wu, Jianguo
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2020
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7694937/ https://ncbi.nlm.nih.gov/pubmed/33243234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00918-w
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Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome

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