STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against pathogen infe...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Wang, Wenbiao, Hu, Dingwen, Wu, Caifeng, Feng, Yuqian, Li, Aixin, Liu, Weiyong, Wang, Yingchong, Chen, Keli, Tian, Mingfu, Xiao, Feng, Zhang, Qi, Shereen, Muhammad Adnan, Chen, Weijie, Pan, Pan, Wan, Pin, Wu, Kailang, Wu, Jianguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080238/
https://ncbi.nlm.nih.gov/pubmed/32187211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008335
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