Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Macrophages in the atheroma region produce matrix metalloproteinases (MMPs) and decrease plaque stability. Tissue oxygen tension decreases in the arterial wall of the atherosclerotic region. Hypoxia inducible factor (HIF)-1α plays a critical role in the transcriptional activation of hypoxia inducibl...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Wei, Shuoyu, Isagawa, Takayuki, Eguchi, Masamichi, Sato, Daisuke, Tsukano, Hiroto, Miyata, Keishi, Oike, Yuichi, Takeda, Norihiko, Ikeda, Satoshi, Kawano, Hiroaki, Maemura, Koji
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693746/
https://ncbi.nlm.nih.gov/pubmed/33153000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8110470
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