Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis

BACKGROUND: Several reports from basic researches and clinical studies have suggested that xanthine oxidase (XO) inhibitors have suppressive effects on cardiovascular diseases. However, the roles of a XO inhibitor, febuxostat (FEB), in the pathogenesis of vascular remodeling and hypertension indepen...

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Bibliographic Details
Published in:Am J Hypertens
Main Authors: Kondo, Masateru, Imanishi, Masaki, Fukushima, Keijo, Ikuto, Raiki, Murai, Yoichi, Horinouchi, Yuya, Izawa-Ishizawa, Yuki, Goda, Mitsuhiro, Zamami, Yoshito, Takechi, Kenshi, Chuma, Masayuki, Ikeda, Yasumasa, Fujino, Hiromichi, Tsuchiya, Koichiro, Ishizawa, Keisuke
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110082/
https://ncbi.nlm.nih.gov/pubmed/30351343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajh/hpy157
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