Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Macrophages in the atheroma region produce matrix metalloproteinases (MMPs) and decrease plaque stability. Tissue oxygen tension decreases in the arterial wall of the atherosclerotic region. Hypoxia inducible factor (HIF)-1α plays a critical role in the transcriptional activation of hypoxia inducibl...

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Detalhes bibliográficos
Publicado no:Biomedicines
Main Authors: Wei, Shuoyu, Isagawa, Takayuki, Eguchi, Masamichi, Sato, Daisuke, Tsukano, Hiroto, Miyata, Keishi, Oike, Yuichi, Takeda, Norihiko, Ikeda, Satoshi, Kawano, Hiroaki, Maemura, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693746/
https://ncbi.nlm.nih.gov/pubmed/33153000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8110470
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