Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia

Macrophages in the atheroma region produce matrix metalloproteinases (MMPs) and decrease plaque stability. Tissue oxygen tension decreases in the arterial wall of the atherosclerotic region. Hypoxia inducible factor (HIF)-1α plays a critical role in the transcriptional activation of hypoxia inducibl...

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Bibliografiske detaljer
Udgivet i:Biomedicines
Main Authors: Wei, Shuoyu, Isagawa, Takayuki, Eguchi, Masamichi, Sato, Daisuke, Tsukano, Hiroto, Miyata, Keishi, Oike, Yuichi, Takeda, Norihiko, Ikeda, Satoshi, Kawano, Hiroaki, Maemura, Koji
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693746/
https://ncbi.nlm.nih.gov/pubmed/33153000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8110470
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