Osteopontin Links Myeloid Activation and Disease Progression in Systemic Sclerosis

Progressive lung fibrosis is a major cause of mortality in systemic sclerosis (SSc) patients, but the underlying mechanisms remain unclear. We demonstrate that immune complexes (ICs) activate human monocytes to promote lung fibroblast migration partly via osteopontin (OPN) secretion, which is amplif...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Gao, Xia, Jia, Guiquan, Guttman, Anna, DePianto, Daryle J., Morshead, Katrina B., Sun, Kai-Hui, Ramamoorthi, Nandhini, Vander Heiden, Jason A., Modrusan, Zora, Wolters, Paul J., Jahreis, Angelika, Arron, Joseph R., Khanna, Dinesh, Ramalingam, Thirumalai R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691442/
https://ncbi.nlm.nih.gov/pubmed/33294861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100140
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