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Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia

Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007). Here we address the basis for the SF-mediated K16 and K17 inductio...

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Detalhes bibliográficos
Main Authors: Kerns, Michelle, DePianto, Daryle, Yamamoto, Masayuki, Coulombe, Pierre A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993737/
https://ncbi.nlm.nih.gov/pubmed/20926689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0153
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