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Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

Epidermolysis bullosa simplex (EBS) is a rare inherited condition in which the epidermis loses its integrity after mechanical trauma. EBS is typified by the dysfunction of intermediate filaments in basal keratinocytes of epidermis. Most cases of EBS are due to mutations in the keratin 5 or 14 gene (...

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Autors principals: Kerns, Michelle L., DePianto, Daryle, Dinkova-Kostova, Albena T., Talalay, Paul, Coulombe, Pierre A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964870/
https://ncbi.nlm.nih.gov/pubmed/17724334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706486104
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