Specific ZNF274 binding interference at SNORD116 activates the maternal transcripts in Prader-Willi syndrome neurons

Prader-Willi syndrome (PWS) is characterized by neonatal hypotonia, developmental delay and hyperphagia/obesity. This disorder is caused by the absence of paternally expressed gene products from chromosome 15q11–q13. We previously demonstrated that knocking out ZNF274, a Kruppel-associated box-A-dom...

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Publicat a:Hum Mol Genet
Autors principals: Langouët, Maéva, Gorka, Dea, Orniacki, Clarisse, Dupont-Thibert, Clémence M, Chung, Michael S, Glatt-Deeley, Heather R, Germain, Noelle, Crandall, Leann J, Cotney, Justin L, Stoddard, Christopher E, Lalande, Marc, Chamberlain, Stormy J
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
General Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689300/
https://ncbi.nlm.nih.gov/pubmed/32977341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa210
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