A pharmacokinetic‐pharmacodynamic study of a single dose of febuxostat in healthy subjects

AIMS: To examine the pharmacokinetic‐phamacodynamic (PK‐PD) relationships of plasma febuxostat and serum urate and the effect of a single dose of the drug on renal excretion and fractional clearance of urate (FCU). METHODS: Blood and urine samples were collected at baseline and up to 145 hours follo...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Kamel, Bishoy, Graham, Garry G., Stocker, Sophie L., Liu, Zhixin, Williams, Kenneth M., Carland, Jane E., Pile, Kevin D., Day, Richard O.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688545/
https://ncbi.nlm.nih.gov/pubmed/32386239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14357
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