Tumor Infiltrating Effector Memory Antigen-Specific CD8(+) T Cells Predict Response to Immune Checkpoint Therapy

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8(+) cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not b...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Principe, Nicola, Kidman, Joel, Goh, Siting, Tilsed, Caitlin M., Fisher, Scott A., Fear, Vanessa S., Forbes, Catherine A., Zemek, Rachael M., Chopra, Abha, Watson, Mark, Dick, Ian M., Boon, Louis, Holt, Robert A., Lake, Richard A., Nowak, Anna K., Lesterhuis, Willem Joost, McDonnell, Alison M., Chee, Jonathan
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688517/
https://ncbi.nlm.nih.gov/pubmed/33262762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.584423
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