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Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites

BACKGROUND: The complex composition of different cell types within a tissue can be estimated by deconvolution of bulk gene expression profiles or with various single-cell sequencing approaches. Alternatively, DNA methylation (DNAm) profiles have been used to establish an atlas for multiple human tis...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Schmidt, Marco, Maié, Tiago, Dahl, Edgar, Costa, Ivan G., Wagner, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687708/
https://ncbi.nlm.nih.gov/pubmed/33234153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00910-4
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