Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity

Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, COVA1-16 is a relatively rare antibody that also cross-neutralizes SARS-CoV. Here, we determined a crystal structure of the COVA1-...

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Publicado en:Immunity
Main Authors: Liu, Hejun, Wu, Nicholas C., Yuan, Meng, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., van Schooten, Jelle, Zhu, Xueyong, Lee, Chang-Chun D., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687367/
https://ncbi.nlm.nih.gov/pubmed/33242394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.10.023
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