An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural constraints in binding the RBD (mode A). However, a small sub...

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Pubblicato in:Cell Rep
Autori principali: Wu, Nicholas C., Yuan, Meng, Liu, Hejun, Lee, Chang-Chun D., Zhu, Xueyong, Bangaru, Sandhya, Torres, Jonathan L., Caniels, Tom G., Brouwer, Philip J.M., van Gils, Marit J., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522650/
https://ncbi.nlm.nih.gov/pubmed/33027617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108274
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