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Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Most antibodies isolated from COVID-19 patients are specific to SARS-CoV-2. COVA1–16 is a relatively rare antibody that also cross-neutralizes SARS-CoV. Here we determined a crystal structure of COVA1–16 Fab with the SARS-CoV-2 RBD, and a negative-stain EM reconstruction with the spike glycoprotein...
Kaydedildi:
| Yayımlandı: | bioRxiv |
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| Asıl Yazarlar: | , , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7418720/ https://ncbi.nlm.nih.gov/pubmed/32793906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.02.233536 |
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