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CD4(+) T Cell Help Selectively Enhances High Avidity Tumor Antigen-Specific CD8(+) T Cells

Maintaining anti-tumor immunity remains a persistent impediment to cancer immunotherapy. We and others have previously reported that high avidity CD8(+) T cells are more susceptible to tolerance induction in the tumor microenvironment. In the current study, we used a novel model where T cells derive...

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Bibliografski detalji
Izdano u:J Immunol
Glavni autori: Zhu, Ziqiang, Cuss, Steven M., Singh, Vinod, Gurusamy, Devikala, Shoe, Jennifer L., Leighty, Robert, Bronte, Vincenzo, Hurwitz, Arthur A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687044/
https://ncbi.nlm.nih.gov/pubmed/26320256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401571
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