Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Activation of the P53 pathway through inhibition of MDM2 using nutlins has shown clinical promise in the treatment of solid tumors and hematologic malignancies. There is concern, however, that nutlin therapy might stimulate the emergence or expansion of TP53-mutated subclones. We recently published...

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Gepubliceerd in:Blood Adv
Hoofdauteurs: Marcellino, Bridget K., Farnoud, Noushin, Cassinat, Bruno, Lu, Min, Verger, Emanuelle, McGovern, Erin, Patel, Minal, Medina-Martinez, Juan, Levine, Max Fine, Arango Ossa, Juanes E., Zhou, Yangyu, Kosiorek, Heidi, Mehrotra, Meenakshi, Houldsworth, Jane, Dueck, Amylou, Rossi, Michael, Mascarenhas, John, Kiladjian, Jean-Jacques, Rampal, Raajit K., Hoffman, Ronald
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686898/
https://ncbi.nlm.nih.gov/pubmed/33216890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002379
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