Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Activation of the P53 pathway through inhibition of MDM2 using nutlins has shown clinical promise in the treatment of solid tumors and hematologic malignancies. There is concern, however, that nutlin therapy might stimulate the emergence or expansion of TP53-mutated subclones. We recently published...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Marcellino, Bridget K., Farnoud, Noushin, Cassinat, Bruno, Lu, Min, Verger, Emanuelle, McGovern, Erin, Patel, Minal, Medina-Martinez, Juan, Levine, Max Fine, Arango Ossa, Juanes E., Zhou, Yangyu, Kosiorek, Heidi, Mehrotra, Meenakshi, Houldsworth, Jane, Dueck, Amylou, Rossi, Michael, Mascarenhas, John, Kiladjian, Jean-Jacques, Rampal, Raajit K., Hoffman, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686898/
https://ncbi.nlm.nih.gov/pubmed/33216890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002379
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