Transient expansion of TP53 mutated clones in polycythemia vera patients treated with idasanutlin

Activation of the P53 pathway through inhibition of MDM2 using nutlins has shown clinical promise in the treatment of solid tumors and hematologic malignancies. There is concern, however, that nutlin therapy might stimulate the emergence or expansion of TP53-mutated subclones. We recently published...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Marcellino, Bridget K., Farnoud, Noushin, Cassinat, Bruno, Lu, Min, Verger, Emanuelle, McGovern, Erin, Patel, Minal, Medina-Martinez, Juan, Levine, Max Fine, Arango Ossa, Juanes E., Zhou, Yangyu, Kosiorek, Heidi, Mehrotra, Meenakshi, Houldsworth, Jane, Dueck, Amylou, Rossi, Michael, Mascarenhas, John, Kiladjian, Jean-Jacques, Rampal, Raajit K., Hoffman, Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686898/
https://ncbi.nlm.nih.gov/pubmed/33216890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002379
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