Φορτώνει......
Synthesis and SAR of a series of mGlu(7) NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate core
A High-Throughput Screening (HTS) campaign identified a fundamentally new mGlu(7) NAM chemotype, based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinolone carboxylate core. The initial hit, VU0226390, was a potent mGlu(7) NAM (IC(50) = 647 nM, 6% L-AP4 min) with selectivity versus the other gr...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Bioorg Med Chem Lett |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7686273/ https://ncbi.nlm.nih.gov/pubmed/32890686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127529 |
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