Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression

BACKGROUND: Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (XIST) in regulating cellular viability, apoptosis and drug resistance in AML. M...

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Publicado en:Mol Med
Autores principales: Wang, Chong, Li, Lingling, Li, Mengya, Wang, Weiqiong, Liu, Yanfang, Wang, Shujuan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685636/
https://ncbi.nlm.nih.gov/pubmed/33228517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00229-4
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