Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression

BACKGROUND: Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (XIST) in regulating cellular viability, apoptosis and drug resistance in AML. M...

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Bibliografske podrobnosti
izdano v:Mol Med
Main Authors: Wang, Chong, Li, Lingling, Li, Mengya, Wang, Weiqiong, Liu, Yanfang, Wang, Shujuan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685636/
https://ncbi.nlm.nih.gov/pubmed/33228517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00229-4
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