RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development

Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. It is generally considered that CBFβ-SMMHC, the fusion protein encoded by CBFB-MYH11, is a dominant negative repressor of RUNX1. However,...

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Publicat a:Blood
Autors principals: Zhen, Tao, Cao, Yaqiang, Ren, Gang, Zhao, Ling, Hyde, R. Katherine, Lopez, Guadalupe, Feng, Dechun, Alemu, Lemlem, Zhao, Keji, Liu, P. Paul
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685208/
https://ncbi.nlm.nih.gov/pubmed/32929473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020007747
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