CD38 deletion of human primary NK cells eliminates daratumumab-induced fratricide and boosts their effector activity

Multiple myeloma (MM) is a plasma cell neoplasm that commonly expresses CD38. Daratumumab (DARA), a human monoclonal antibody targeting CD38, has significantly improved the outcome of patients with relapsed or refractory MM, but the response is transient in most cases. Putative mechanisms of subopti...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Blood
Hlavní autoři: Naeimi Kararoudi, Meisam, Nagai, Yuya, Elmas, Ezgi, de Souza Fernandes Pereira, Marcelo, Ali, Syed Abbas, Imus, Philip Hollingsworth, Wethington, Darren, Borrello, Ivan Marques, Lee, Dean Anthony, Ghiaur, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685207/
https://ncbi.nlm.nih.gov/pubmed/32603414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006200
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky