Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting

Daratumumab (Dara), a multiple myeloma (MM) therapy, is an antibody against the surface receptor CD38, which is expressed not only on plasma cells but also on NK cells and monocytes. Correlative data have highlighted the immune-modulatory role of Dara, despite the paradoxical observation that Dara r...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Viola, Domenico, Dona, Ada, Caserta, Enrico, Troadec, Estelle, Besi, Francesca, McDonald, Tinisha, Ghoda, Lucy, Gunes, Emine Gulsen, Sanchez, James F, Khalife, Jihane, Martella, Marianna, Karanes, Chatchada, Htut, Myo, Wang, Xiuli, Rosenzweig, Michael, Chowdhury, Arnab, Sborov, Douglas, Miles, Rodney R, Yazaki, Paul J., Ebner, Todd, Hofmeister, Craig C., Forman, Stephen J, Rosen, Steven T, Marcucci, Guido, Shively, John, Keats, Jonathan J, Krishnan, Amrita, Pichiorri, Flavia
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572537/
https://ncbi.nlm.nih.gov/pubmed/32296125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0810-4
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