2B4 inhibits NK-cell fratricide

2B4 (CD244) and its ligand, CD48, are expressed on all natural killer (NK) cells. In studies using 2B4-deficient, CD48-deficient, or wild-type NK cells with blocking antibodies, we found that in the absence of 2B4-CD48 interactions, activated murine NK cells kill each other. We also show that NK-NK...

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Bibliographic Details
Main Authors: Taniguchi, Ruth T., Guzior, Dustin, Kumar, Vinay
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976350/
https://ncbi.nlm.nih.gov/pubmed/17537992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-076927
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