CD38 deletion of human primary NK cells eliminates daratumumab-induced fratricide and boosts their effector activity

Multiple myeloma (MM) is a plasma cell neoplasm that commonly expresses CD38. Daratumumab (DARA), a human monoclonal antibody targeting CD38, has significantly improved the outcome of patients with relapsed or refractory MM, but the response is transient in most cases. Putative mechanisms of subopti...

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發表在:Blood
Main Authors: Naeimi Kararoudi, Meisam, Nagai, Yuya, Elmas, Ezgi, de Souza Fernandes Pereira, Marcelo, Ali, Syed Abbas, Imus, Philip Hollingsworth, Wethington, Darren, Borrello, Ivan Marques, Lee, Dean Anthony, Ghiaur, Gabriel
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2020
主題:
Immunobiology and Immunotherapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685207/
https://ncbi.nlm.nih.gov/pubmed/32603414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006200
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