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Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells

PURPOSE: Lysophosphatidic acid (LPA) and soluble interleukin-6 receptor (sIL6R) are elevated in primary open angle glaucoma (POAG). LPA and IL6 modulate in response to biomechanical stimuli and converge on similar fibrotic phenotypes. Thus, we determined whether LPA and IL6 trans-signaling (IL6/sIL6...

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Bibliografski detalji
Izdano u:Invest Ophthalmol Vis Sci
Glavni autori: Yemanyi, Felix, Raghunathan, VijayKrishna
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683860/
https://ncbi.nlm.nih.gov/pubmed/33216119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.13.29
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