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Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells

PURPOSE: Lysophosphatidic acid (LPA), a bioactive lipid, has been shown to increase resistance to aqueous humor outflow (AH) through the trabecular meshwork (TM). The molecular basis for this response of the TM to LPA, however, is not completely understood. In this study, we explored the possible in...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Principais autores: Ho, Leona T. Y., Skiba, Nikolai, Ullmer, Christoph, Rao, Ponugoti Vasantha
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896423/
https://ncbi.nlm.nih.gov/pubmed/29677358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-23702
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