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Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways

PURPOSE: The purpose of this study was to determine whether genipin-induced crosslinked cell-derived matrix (XCDM) precipitates fibrotic phenotypes in human trabecular meshwork (hTM) cells by dysregulating β-catenin and Yes-associated protein (YAP)/ transcriptional coactivator with PDZ-binding motif...

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Foilsithe in:Invest Ophthalmol Vis Sci
Main Authors: Yemanyi, Felix, Vranka, Janice, Raghunathan, Vijay Krishna
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Association for Research in Vision and Ophthalmology 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452853/
https://ncbi.nlm.nih.gov/pubmed/32832971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.10.41
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