Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering

Lentiviral vectors (LVs) are increasingly employed in gene and cell therapy. Standard laboratory production of LVs is not easily scalable, and research-grade LVs often contain contaminants that can interfere with downstream applications. Moreover, purified LV production pipelines have been developed...

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Publicat a:Mol Ther Methods Clin Dev
Autors principals: Soldi, Monica, Sergi Sergi, Lucia, Unali, Giulia, Kerzel, Thomas, Cuccovillo, Ivan, Capasso, Paola, Annoni, Andrea, Biffi, Mauro, Rancoita, Paola Maria Vittoria, Cantore, Alessio, Lombardo, Angelo, Naldini, Luigi, Squadrito, Mario Leonardo, Kajaste-Rudnitski, Anna
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683235/
https://ncbi.nlm.nih.gov/pubmed/33294490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.009
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