In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney failure. The currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative treatments. The sign...

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Опубликовано в: :J Mol Cell Biol
Главные авторы: Booij, Tijmen H, Leonhard, Wouter N, Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J, Veraar, Kimberley A M, Dauwerse, Johannes G, van Westen, Gerard J P, van de Water, Bob, Price, Leo S, Peters, Dorien J M
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683017/
https://ncbi.nlm.nih.gov/pubmed/31065693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz029
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