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Using B cell receptor lineage structures to predict affinity

We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic for a novel pathogen, for instance, we might look for such antibodies in patients that have recovered. There exist effecti...

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書目詳細資料
發表在:PLoS Comput Biol
Main Authors: Ralph, Duncan K., Matsen, Frederick A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682889/
https://ncbi.nlm.nih.gov/pubmed/33175831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008391
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